Which type of adverse event could be classified as immune-related in immunotherapy?

• A. Hypotension
• B. Dermatitis
• C. Constipation
• D. Anorexia

Answer: (B)

Immune-related adverse events in immunotherapy are a result of the therapeutic agent activating the immune system, which can lead to inflammation and tissue damage in various organs. Dermatitis is a clear manifestation of this immune activation, often presenting as rash or skin inflammation.

The skin is a common target for immune-related events due to the presence of immune cells in the dermis and epidermis. When immunotherapy enhances T-cell activity, this can trigger an inflammatory response in the skin, leading to conditions such as dermatitis. Therefore, when considering the types of adverse events that are classified as immune-related, dermatitis stands out as a direct result of immune system activation.

In contrast, the other options—hypotension, constipation, and anorexia—are generally not classified as immune-related adverse events. Hypotension typically relates more to cardiovascular responses rather than immune activation, while constipation and anorexia are more likely outcomes from non-specific factors such as drug side effects, and they do not directly reflect immune-mediated mechanisms.